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Do not take Tofranil with any of the following medications:

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  • cisapride
  • cocaine
  • grepafloxacin
  • halofantrine
  • levomethadyl
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  • other medicines for mental depression
  • phenothiazines like perphenazine, thioridazine and chlorpromazine
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Tofranil may also interact with the following medications:

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  • barbiturate medicines for inducing sleep or treating seizures like phenobarbital
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  • stimulants like dexmethylphenidate or methylphenidate
  • thyroid hormones

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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